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Thames Valley Police is appealing for witnesses and dash-cam footage following a fatal RTC on the M40 in South Buckinghamshire.
At around 8.15am, there was a collision involving around eight vehicles on the M40 between J5 and J4 southbound.
Sadly, a woman in her sixties and a man in his seventies, died at the scene. Their next of kin has been informed and is being supported by specially trained officers.
A further two people sustained serious injuries and were taken to hospital where they remain.
10 people sustained minor injuries, a number of who were taken to hospital for additional checks.
Detective Chief Inspector Mike Bettington, of the Joint Operations Roads Policing Unit, said: “Our thoughts remain with the family and friends of the two people who died.
“We are appealing to anyone who may have witnessed the collision, or who may have dash-cam footage, to please get in touch.
“You can do this by calling 101 or making a report online, quoting reference 43230032159.”