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Thames Valley Police is appealing for witnesses after a road traffic collision near Aston Clinton.
At around 10.30am on Sunday (12/11), a blue Renault Clio and a white Skoda Yeti were involved in the collision at the junction of London Road, Tring Hill and Upper Icknield Way.
The two drivers, two women, one in her late teens and the other in her eighties, both suffered serious injuries and were taken to Stoke Mandeville Hospital, where they both remain.
No one else was injured and no arrests have been made.
Investigating officer PC Nicholas Gent, of the Joint Operations Roads Policing Unit, said: “I am appealing to anyone who may have witnessed this incident to please come forward.
“I’d also ask any motorists with dash-cams who were driving in the area at the time of the collision to please check their recordings in case they have captured something that could assist the investigation. You can send footage to us using this online portal.
“To get in touch, please call 101 or fill in our online form, quoting reference number 43230508839.”
JD